The R Protein of SARS-CoV: Analyses of Structure and Function Based on Four Complete Genome Sequences of Isolates BJ01-BJ04
Identifieur interne : 005D54 ( Main/Exploration ); précédent : 005D53; suivant : 005D55The R Protein of SARS-CoV: Analyses of Structure and Function Based on Four Complete Genome Sequences of Isolates BJ01-BJ04
Auteurs : Zuyuan Xu [République populaire de Chine] ; Haiqing Zhang [République populaire de Chine] ; Xiangjun Tian [République populaire de Chine] ; Jia Ji [République populaire de Chine] ; Wei Li [République populaire de Chine] ; Yan Li [République populaire de Chine] ; Wei Tian [République populaire de Chine] ; Yujun Han [République populaire de Chine] ; Lili Wang [République populaire de Chine] ; Zizhang Zhang [République populaire de Chine] ; Jing Xu [République populaire de Chine] ; Wei Wei [République populaire de Chine] ; Jingui Zhu [République populaire de Chine] ; Haiyan Sun [République populaire de Chine] ; Xiaowei Zhang [République populaire de Chine] ; Jun Zhou [République populaire de Chine] ; Songgang Li [République populaire de Chine] ; Jun Wang [République populaire de Chine] ; Jian Wang [République populaire de Chine] ; Shengli Bi [République populaire de Chine] ; Huanming Yang [République populaire de Chine]Source :
- Genomics, Proteomics & Bioinformatics [ 1672-0229 ] ; 2003.
Descripteurs français
- KwdFr :
- Analyse de regroupements, Analyse de séquence d'ADN, Biologie informatique, Composants de gène, Composition en bases nucléiques, Données de séquences moléculaires, Génome viral, Mutation (génétique), Phylogénie, RNA replicase (génétique), Structure tertiaire des protéines, Séquence conservée (génétique), Séquence d'acides aminés, Séquence nucléotidique, Virus du SRAS (génétique), Évolution moléculaire.
- MESH :
- génétique : Mutation, RNA replicase, Séquence conservée, Virus du SRAS.
- Analyse de regroupements, Analyse de séquence d'ADN, Biologie informatique, Composants de gène, Composition en bases nucléiques, Données de séquences moléculaires, Génome viral, Phylogénie, Structure tertiaire des protéines, Séquence d'acides aminés, Séquence nucléotidique, Évolution moléculaire.
English descriptors
- KwdEn :
- Amino Acid Sequence, Base Composition, Base Sequence, Cluster Analysis, Computational Biology, Conserved Sequence (genetics), Evolution, Molecular, Gene Components, Genome, Viral, Molecular Sequence Data, Mutation (genetics), Phylogeny, Protein Structure, Tertiary, RNA Replicase (genetics), SARS Virus (genetics), Sequence Analysis, DNA.
- MESH :
- chemical , genetics : RNA Replicase.
- genetics : Conserved Sequence, Mutation, SARS Virus.
- Amino Acid Sequence, Base Composition, Base Sequence, Cluster Analysis, Computational Biology, Evolution, Molecular, Gene Components, Genome, Viral, Molecular Sequence Data, Phylogeny, Protein Structure, Tertiary, Sequence Analysis, DNA.
Abstract
The R (replicase) protein is the uniquely defined non-structural protein (NSP) responsible for RNA replication, mutation rate or fidelity, regulation of transcription in coronaviruses and many other ssRNA viruses. Based on our complete genome sequences of four isolates (BJ01-BJ04) of SARS-CoV from Beijing, China, we analyzed the structure and predicted functions of the R protein in comparison with 13 other isolates of SARS-CoV and 6 other coronaviruses. The entire ORF (open-reading frame) encodes for two major enzyme activities, RNA-dependent RNA polymerase (RdRp) and proteinase activities. The R polyprotein undergoes a complex proteolytic process to produce 15 function-related peptides. A hydrophobic domain (HOD) and a hydrophilic domain (HID) are newly identified within NSP1. The substitution rate of the R protein is close to the average of the SARS-CoV genome. The functional domains in all NSPs of the R protein give different phylogenetic results that suggest their different mutation rate under selective pressure. Eleven highly conserved regions in RdRp and twelve cleavage sites by 3CLP (chymotrypsin-like protein) have been identified as potential drug targets. Findings suggest that it is possible to obtain information about the phylogeny of SARS-CoV, as well as potential tools for drug design, genotyping and diagnostics of SARS.
Url:
DOI: 10.1016/S1672-0229(03)01019-2
PubMed: 15626345
PubMed Central: 5172245
Affiliations:
- République populaire de Chine
- Pékin, Zhejiang
- Hangzhou, Pékin
- Université de Pékin, Université de Zhejiang
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Le document en format XML
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Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Bi, Shengli" sort="Bi, Shengli" uniqKey="Bi S" first="Shengli" last="Bi">Shengli Bi</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Center of Disease Control and Prevention, Beijing 100050, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Disease Control and Prevention, Beijing 100050</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0010">James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15626345</idno><idno type="pmc">5172245</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172245</idno><idno type="RBID">PMC:5172245</idno><idno type="doi">10.1016/S1672-0229(03)01019-2</idno><date when="2003">2003</date><idno type="wicri:Area/Pmc/Corpus">001029</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001029</idno><idno type="wicri:Area/Pmc/Curation">001029</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001029</idno><idno type="wicri:Area/Pmc/Checkpoint">001782</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001782</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:15626345</idno><idno type="wicri:Area/PubMed/Corpus">002981</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002981</idno><idno type="wicri:Area/PubMed/Curation">002981</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002981</idno><idno type="wicri:Area/PubMed/Checkpoint">003032</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003032</idno><idno type="wicri:Area/Ncbi/Merge">000C84</idno><idno type="wicri:Area/Ncbi/Curation">000C84</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C84</idno><idno type="wicri:doubleKey">1672-0229:2003:Xu Z:the:r:protein</idno><idno type="wicri:Area/Main/Merge">006226</idno><idno type="wicri:Area/Main/Curation">005D54</idno><idno type="wicri:Area/Main/Exploration">005D54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The R Protein of SARS-CoV: Analyses of Structure and Function Based on Four Complete Genome Sequences of Isolates BJ01-BJ04</title><author><name sortKey="Xu, Zuyuan" sort="Xu, Zuyuan" uniqKey="Xu Z" first="Zuyuan" last="Xu">Zuyuan Xu</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0010">James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhang, Haiqing" sort="Zhang, Haiqing" uniqKey="Zhang H" first="Haiqing" last="Zhang">Haiqing Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tian, Xiangjun" sort="Tian, Xiangjun" uniqKey="Tian X" first="Xiangjun" last="Tian">Xiangjun Tian</name><affiliation wicri:level="4"><nlm:aff id="aff0010">James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ji, Jia" sort="Ji, Jia" uniqKey="Ji J" first="Jia" last="Ji">Jia Ji</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tian, Wei" sort="Tian, Wei" uniqKey="Tian W" first="Wei" last="Tian">Wei Tian</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0010">James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Medical College, Xi’an Jiaotong University, Xi’an 710049, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical College, Xi’an Jiaotong University, Xi’an 710049</wicri:regionArea><wicri:noRegion>Xi’an 710049</wicri:noRegion></affiliation></author><author><name sortKey="Han, Yujun" sort="Han, Yujun" uniqKey="Han Y" first="Yujun" last="Han">Yujun Han</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Zizhang" sort="Zhang, Zizhang" uniqKey="Zhang Z" first="Zizhang" last="Zhang">Zizhang Zhang</name><affiliation wicri:level="4"><nlm:aff id="aff0010">James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Xu, Jing" sort="Xu, Jing" uniqKey="Xu J" first="Jing" last="Xu">Jing Xu</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name><affiliation wicri:level="4"><nlm:aff id="aff0010">James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhu, Jingui" sort="Zhu, Jingui" uniqKey="Zhu J" first="Jingui" last="Zhu">Jingui Zhu</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Sun, Haiyan" sort="Sun, Haiyan" uniqKey="Sun H" first="Haiyan" last="Sun">Haiyan Sun</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Xiaowei" sort="Zhang, Xiaowei" uniqKey="Zhang X" first="Xiaowei" last="Zhang">Xiaowei Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhou, Jun" sort="Zhou, Jun" uniqKey="Zhou J" first="Jun" last="Zhou">Jun Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Songgang" sort="Li, Songgang" uniqKey="Li S" first="Songgang" last="Li">Songgang Li</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0020">College of Life Sciences, Peking University, Beijing 100871, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Peking University, Beijing 100871</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0010">James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Bi, Shengli" sort="Bi, Shengli" uniqKey="Bi S" first="Shengli" last="Bi">Shengli Bi</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Center of Disease Control and Prevention, Beijing 100050, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Disease Control and Prevention, Beijing 100050</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0010">James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></analytic><series><title level="j">Genomics, Proteomics & Bioinformatics</title><idno type="ISSN">1672-0229</idno><idno type="eISSN">2210-3244</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Base Composition</term><term>Base Sequence</term><term>Cluster Analysis</term><term>Computational Biology</term><term>Conserved Sequence (genetics)</term><term>Evolution, Molecular</term><term>Gene Components</term><term>Genome, Viral</term><term>Molecular Sequence Data</term><term>Mutation (genetics)</term><term>Phylogeny</term><term>Protein Structure, Tertiary</term><term>RNA Replicase (genetics)</term><term>SARS Virus (genetics)</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de regroupements</term><term>Analyse de séquence d'ADN</term><term>Biologie informatique</term><term>Composants de gène</term><term>Composition en bases nucléiques</term><term>Données de séquences moléculaires</term><term>Génome viral</term><term>Mutation (génétique)</term><term>Phylogénie</term><term>RNA replicase (génétique)</term><term>Structure tertiaire des protéines</term><term>Séquence conservée (génétique)</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Virus du SRAS (génétique)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA Replicase</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conserved Sequence</term><term>Mutation</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mutation</term><term>RNA replicase</term><term>Séquence conservée</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Base Composition</term><term>Base Sequence</term><term>Cluster Analysis</term><term>Computational Biology</term><term>Evolution, Molecular</term><term>Gene Components</term><term>Genome, Viral</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Protein Structure, Tertiary</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de regroupements</term><term>Analyse de séquence d'ADN</term><term>Biologie informatique</term><term>Composants de gène</term><term>Composition en bases nucléiques</term><term>Données de séquences moléculaires</term><term>Génome viral</term><term>Phylogénie</term><term>Structure tertiaire des protéines</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The R (replicase) protein is the uniquely defined non-structural protein (NSP) responsible for RNA replication, mutation rate or fidelity, regulation of transcription in coronaviruses and many other ssRNA viruses. Based on our complete genome sequences of four isolates (BJ01-BJ04) of SARS-CoV from Beijing, China, we analyzed the structure and predicted functions of the R protein in comparison with 13 other isolates of SARS-CoV and 6 other coronaviruses. The entire ORF (open-reading frame) encodes for two major enzyme activities, RNA-dependent RNA polymerase (RdRp) and proteinase activities. The R polyprotein undergoes a complex proteolytic process to produce 15 function-related peptides. A hydrophobic domain (HOD) and a hydrophilic domain (HID) are newly identified within NSP1. The substitution rate of the R protein is close to the average of the SARS-CoV genome. The functional domains in all NSPs of the R protein give different phylogenetic results that suggest their different mutation rate under selective pressure. Eleven highly conserved regions in RdRp and twelve cleavage sites by 3CLP (chymotrypsin-like protein) have been identified as potential drug targets. Findings suggest that it is possible to obtain information about the phylogeny of SARS-CoV, as well as potential tools for drug design, genotyping and diagnostics of SARS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cavanngh, D" uniqKey="Cavanngh D">D. Cavanngh</name></author><author><name sortKey="Brown, T D K" uniqKey="Brown T">T.D.K. Brown</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, E D" uniqKey="Qin E">E.D. Qin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brierley, I" uniqKey="Brierley I">I. Brierley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Norman, M" uniqKey="Norman M">M. Norman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Myers, E" uniqKey="Myers E">E. Myers</name></author><author><name sortKey="Miller, W" uniqKey="Miller W">W. Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, K P" uniqKey="Lim K">K.P. Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jens, H" uniqKey="Jens H">H. Jens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A. Kanjanahaluethai</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rueckert, R R" uniqKey="Rueckert R">R.R. Rueckert</name></author><author><name sortKey="Wimmer, E" uniqKey="Wimmer E">E. Wimmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Meer" uniqKey="Van Der Meer">van der Meer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pedersen, K W" uniqKey="Pedersen K">K.W. Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raamsman, M J" uniqKey="Raamsman M">M.J. Raamsman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E. De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, M P" uniqKey="Walker M">M.P. Walker</name></author><author><name sortKey="Hong, Z" uniqKey="Hong Z">Z. Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E. De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruenn, J A" uniqKey="Bruenn J">J.A. Bruenn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Den Boon, J A" uniqKey="Den Boon J">J.A. Den Boon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Q Y" uniqKey="Zhu Q">Q.Y. Zhu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Pékin</li><li>Zhejiang</li></region><settlement><li>Hangzhou</li><li>Pékin</li></settlement><orgName><li>Université de Pékin</li><li>Université de Zhejiang</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xu, Zuyuan" sort="Xu, Zuyuan" uniqKey="Xu Z" first="Zuyuan" last="Xu">Zuyuan Xu</name></noRegion><name sortKey="Bi, Shengli" sort="Bi, Shengli" uniqKey="Bi S" first="Shengli" last="Bi">Shengli Bi</name><name sortKey="Han, Yujun" sort="Han, Yujun" uniqKey="Han Y" first="Yujun" last="Han">Yujun Han</name><name sortKey="Ji, Jia" sort="Ji, Jia" uniqKey="Ji J" first="Jia" last="Ji">Jia Ji</name><name sortKey="Li, Songgang" sort="Li, Songgang" uniqKey="Li S" first="Songgang" last="Li">Songgang Li</name><name sortKey="Li, Songgang" sort="Li, Songgang" uniqKey="Li S" first="Songgang" last="Li">Songgang Li</name><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><name sortKey="Sun, Haiyan" sort="Sun, Haiyan" uniqKey="Sun H" first="Haiyan" last="Sun">Haiyan Sun</name><name sortKey="Tian, Wei" sort="Tian, Wei" uniqKey="Tian W" first="Wei" last="Tian">Wei Tian</name><name sortKey="Tian, Wei" sort="Tian, Wei" uniqKey="Tian W" first="Wei" last="Tian">Wei Tian</name><name sortKey="Tian, Wei" sort="Tian, Wei" uniqKey="Tian W" first="Wei" last="Tian">Wei Tian</name><name sortKey="Tian, Xiangjun" sort="Tian, Xiangjun" uniqKey="Tian X" first="Xiangjun" last="Tian">Xiangjun Tian</name><name sortKey="Tian, Xiangjun" sort="Tian, Xiangjun" uniqKey="Tian X" first="Xiangjun" last="Tian">Xiangjun Tian</name><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name><name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name><name sortKey="Xu, Jing" sort="Xu, Jing" uniqKey="Xu J" first="Jing" last="Xu">Jing Xu</name><name sortKey="Xu, Zuyuan" sort="Xu, Zuyuan" uniqKey="Xu Z" first="Zuyuan" last="Xu">Zuyuan Xu</name><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name><name sortKey="Zhang, Haiqing" sort="Zhang, Haiqing" uniqKey="Zhang H" first="Haiqing" last="Zhang">Haiqing Zhang</name><name sortKey="Zhang, Xiaowei" sort="Zhang, Xiaowei" uniqKey="Zhang X" first="Xiaowei" last="Zhang">Xiaowei Zhang</name><name sortKey="Zhang, Zizhang" sort="Zhang, Zizhang" uniqKey="Zhang Z" first="Zizhang" last="Zhang">Zizhang Zhang</name><name sortKey="Zhou, Jun" sort="Zhou, Jun" uniqKey="Zhou J" first="Jun" last="Zhou">Jun Zhou</name><name sortKey="Zhu, Jingui" sort="Zhu, Jingui" uniqKey="Zhu J" first="Jingui" last="Zhu">Jingui Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|type= RBID
|clé= PMC:5172245
|texte= The R Protein of SARS-CoV: Analyses of Structure and Function Based on Four Complete Genome Sequences of Isolates BJ01-BJ04
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:15626345" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |